Green Chemistry at CSC2017 – The 100th Canadian Chemistry Conference and Exhibition

By Kevin Szkop and Alex Waked

This year, the GCI partnered with the Chemical Institute of Canada (CIC), the organizing body of the CSC2017, to be closely involved in various aspects of Canada’s largest chemistry meeting.

In collaboration with GreenCentre Canada and CIC, the GCI organized a Professional Development Workshop as part of the CSC2017 program. This event consisted of four components:

The green chemistry crash course, led by Dr. Laura Reyes. Laura is a founding member of the GCI, and is now working in marketing & communications with GreenCentre Canada.

A case study, led by Dr. Tim Clark, Technology Leader at GreenCentre Canada. The case study gave attendees a unique opportunity to learn about some projects that GreenCentre has been developing and in collaboration with peers, learn how to find applications for new intellectual property (IP) and how to make contacts within relevant companies.

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Dr. Tim Clark leading the GreenCentre Canada Industry Case Study

Career panel discussion, sponsored by Gilead, featuring members of academia and industry.

A coffee mixer for an opportunity for informal networking.

 

Supplementary to the Professional Development Workshop, the GCI organized a technical session, co-hosted by the Inorganic, Environmental, and Industrial sections of the conference. This new symposium, entitled “Recent Advances in Sustainable Chemistry”, brought together students, professors, industry, and government speakers to showcase a diverse and engaging collection of new trends in green and sustainable chemistry practices across all sectors of chemistry. Highlighted talks included Dr. Martyn Poliakoff from the University of Nottingham, also a CSC2017 Plenary Lecturer, Dr. David Bergbreiter from Texas A&M University, and Dr. William Tolman from the University of Minnesota.

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Dr. Martyn Poliakoff teaching the audience about NbOPO4 acid catalysts found in Brazilian mines

Dr. Bergbreiter’s lecture was an engaging one. His enthusiastic approach to the use of renewable and bio-derived polymers as green solvents was captivating to both industrial and academic chemists.

Dr. Martyn Poliakoff, a plenary speaker at the conference, gave a phenomenal talk during the first day of the symposium. His charismatic style complimented perfectly the cutting-edge research ongoing in his group at the University of Nottingham. Particularly interesting was the use of flow processes in tandem with photochemistry to yield large quantities of natural products useful in the drug industries.

Dr. Tolman’s talk was of interest to essentially anyone working in an academic environment, especially for student run groups, like the GCI, with both academic interests as well as safety awareness initiatives. In the first part of the talk, synthetic and mechanistic studies of renewable polymers were discussed. The second part shifted focus to student-led efforts to enhance the safety culture in academic labs, which stood out from most of the other talks in our symposium.

One highlight was a group of graduate students at the University of Minnesota organizing a tour of Dow Chemicals to observe the work and safety codes in an industrial setting, which they used as a lesson to bring back to their own research labs. This caught the eye of most of the GCI members, which inspired us to organize a similar day trip in the future.

In further efforts to make our symposium accessible to undergraduate and graduate students, the GCI partnered with GreenCentre Canada to award five Travel Scholarships to deserving students from across Canada to provide financial aid to participate in the conference.

We thank all of our speakers, both national and international, for their participation in the program. It was a great success!

 

All Wrapped Up – Catalyst-Containing Wax Capsules Instead of Glove Boxes

All Wrapped Up – Catalyst-Containing Wax Capsules Instead of Glove Boxes

By Kevin Szkop, Symposium Coordinator for the GCI

What if you could do air-sensitive chemistry without a glove box or Schlenk line?

This is the idea behind the company XiMo, launched by Amir Hoveyda from Boston College, Richard Schrock from MIT and their co-workers.

Schrock, Hoveyda and many others work in the area of making carbon-carbon bonds.  The carbon-carbon bond is ubiquitous in nature, found in (nearly) every organic and naturally occurring molecule. The complexity of design that can be obtained from a seemingly simple chemical bond is unparalleled. The formation of carbon-carbon bonds is very important in the manufacturing of pharmaceuticals, food and natural products, agricultural chemicals, materials, and more. Notably, synthetic organic and inorganic chemists work together to design catalysts that are able to carry out this priceless transformation.

There have been many advances in this regard, especially in the field of coupling reactions and bond metathesis (the swapping of partners by a re-distribution of alkene and alkyne groups), both endeavours earning their discoverers Nobel prizes.1,2 However, a shortcoming in this field is the air- and moisture-sensitivity of the catalysts that need to be used for these transformations. The typical way of overcoming this problem is through the use of a glove box.

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Typical glove box used to protect air- and moisture-sensitive materials.

A glove box is an essential piece of laboratory equipment to the synthetic chemist. By providing an air- and moisture-free environment, sensitive chemistry can easily be performed.
While useful, glove boxes are expensive to buy and operate, require a lot of inert gas (argon or nitrogen) to maintain a clean and dry working atmosphere, and a lot of upkeep is needed to maintain their successful operation.

 

In efforts to address these issues, Amir Hoyveda from Boston College, Richard Schrock from MIT, and coworkers have launched the company XiMo3, which manufactures paraffin tablets containing air and moisture sensitive materials. Using less rigorous techniques for the exclusion of air and moisture from the reaction vessel than a glove box, the organic chemist can simply add the tablet to the desired reaction. The tablets will release their contents in the reaction solvent under mild heating conditions. Therefore, even though precautions must be taken, the overall process eliminates the need for a glove box.4

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Paraffin wax tablet

Many different factors affect the integrity of the paraffin wax tablets. The active compound must be able to dissolve in the reaction medium and release its contents under desirable conditions, it must be air- and water-stable, and the active compounds must be homogeneously dispersed within the volume of the tablet, but not on the surface. These problems have all been overcome since the company’s founding in 2005.

Some of the commercially available catalysts (shown below) are widely used in metathesis reactions for the construction of complex molecular carbon backbones.5,6,7 These reagents have been successfully incorporated into a paraffin tablet and show equivalent activity in selected reactions compared to the traditional catalyst in reactions performed under air- and moisture-free conditions.

 

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Typical metathesis catalysts embedded in paraffin wax tablets.

The company’s founders hope that this new technology will speed up research and development endeavours, particularly in the field of drug synthesis. Bypassing the need for a glovebox, the paraffin tablets will allow a wide range of organic chemists to explore the rich chemistry obtainable by these air sensitive catalysts.

 

References

  1. http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2005/
  2. http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2010/
  3. XiMo Technologies: http://www.ximo-inc.com/technology-updates
  4. Chemistry World News, Oct. 2016: https://www.chemistryworld.com/news/wax-pills-for-safe-and-simple-olefin-metathesis-hit-the-market/1017567.article
  5. Koh, M.-J.; Nguyen, T. T.; Zhang, H.; Schrock, R. R.; Hoveyda, A. H.Nature2016, 531,
  6. Lam, C. Zhu, K. V. Bukhryakov, P. Müller, A. H. Hoveyda, R. R. SchrockJ. Am. Chem. Soc. 2016, 138, 15774.
  7. T. Nguyen, M. J. Koh, X. Shen, F. Romiti, R. R. Schrock, A. H. HoveydaScience, 2016, 352, 569.